Tricyclic antidepressants help prevent migraines from happening as frequently by maintaining a healthy serotonin level. Note the word frequently. While we're hopeful that one day there will be a migraine cure, we recommend working with a doctor to find the right migraine treatment plan for you. Many people start to see results within one month and one study published in the National Institute of Health shows they become more effective the longer you take them—six months to be exact. If you don't see results within two months, reach out to your doctor to discuss other treatment options.
Antidepressants are a long-term preventive treatment that need to be taken at the same time every day. Because they can cause drowsiness, many people prefer to take them before bed. Antidepressants are a good treatment option for migraine sufferers who endure several migraines a month, who can't use acute treatment at all, or who need additional treatment support beyond acute medication.
While antidepressants are generally considered safe and effective, there are people who should consider other migraine treatments. But we're committed to providing you with the best migraine care, and in this case, that means not making any claims we can't stand by.
While antidepressants are generally considered safe, like many medications, there are possible side effects. These could include:. You should immediately contact your doctor if you experience signs of serious allergic reaction, dizziness, or difficulty breathing while taking these medications.
Amitriptyline has been used to treat migraines for longer than any other tricyclic antidepressant. Nortriptyline , a commonly prescribed alternative to amitriptyline, also has a strong track record. But migraines are personal, so the best antidepressant for someone else may not be the best for you. Ask a Cove doctor about your options for a personalized recommendation.
We know this can feel like a lot of information to process, and you may still have questions. Cove works with licensed doctors to help each and every person find a treatment plan that helps them feel more in control of their condition.
If you'd like to read about other options, we recommend checking out our migraine treatment resource to read up on: triptans , NSAIDs , beta blockers , and anticonvulsants. Side effects of antidepressants vary from one medication to another and from person to person.
Side effects may include weight gain, fatigue, constipation and dry mouth. Such side effects can make it difficult to stick with treatment. If the medication doesn't seem to be working or is causing bothersome side effects, talk to your doctor. Don't stop taking a prescribed medication without talking to your doctor first. Jerry W. Swanson, M.
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Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. It affects people of all ages, but the symptoms in children can be different than those in adults. Migraine headaches are common after traumatic brain injuries like concussions.
Persistent migraine headaches in particular can have a big effect on…. Health Conditions Discover Plan Connect. Treating Migraines with Antidepressants. Medically reviewed by Seunggu Han, M. Despite their name, antidepressants may treat a variety of conditions besides depression, including: anxiety and panic disorders eating disorders insomnia chronic pain hot flashes Antidepressants may also effectively prevent migraines.
What are the different types? How do antidepressants prevent migraines? What are the side effects of antidepressants? Are antidepressants safe? The bottom line. How to Manage Treatment-Resistant Depression.
Combination Medication Therapies for Depression. Read this next. Tricyclic Antidepressants. Medically reviewed by Zara Risoldi Cochrane, Pharm. Employment and work impact of chronic migraine and episodic migraine.
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